Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.020 GeneticVariation disease BEFREE While, obesity and increased HOMA-IR may be risk factors in DTC development, we suggest that IRS-1, IRS-2 and IGFBP-3 gene polymorphisms do not play an important role in pathogenesis of DTC. 24504452 2014
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
0.010 GeneticVariation disease BEFREE While, obesity and increased HOMA-IR may be risk factors in DTC development, we suggest that IRS-1, IRS-2 and IGFBP-3 gene polymorphisms do not play an important role in pathogenesis of DTC. 24504452 2014
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.010 GeneticVariation disease BEFREE While, obesity and increased HOMA-IR may be risk factors in DTC development, we suggest that IRS-1, IRS-2 and IGFBP-3 gene polymorphisms do not play an important role in pathogenesis of DTC. 24504452 2014
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
0.010 AlteredExpression disease BEFREE When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. 29137300 2017
Entrez Id: 23598
Gene Symbol: PATZ1
PATZ1
0.010 Biomarker disease BEFREE When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. 29137300 2017
Entrez Id: 128869
Gene Symbol: PIGU
PIGU
0.010 Biomarker disease BEFREE We used a multivariable logistic regression model to study the role of PIGU in the response to RAI treatment in advanced DTC.All statistical tests were two-sided. 30053080 2017
Entrez Id: 79921
Gene Symbol: TCEAL4
TCEAL4
0.010 AlteredExpression disease BEFREE We suggest that loss of TCEAL4 expression might be associated with development of ATC from DTC. 17076909 2006
Entrez Id: 7158
Gene Symbol: TP53BP1
TP53BP1
0.010 Biomarker disease BEFREE We studied the induction, persistence, and disappearance of radiation-induced gamma-H2AX and 53BP1 foci after the first (131)I therapy of patients with differentiated thyroid carcinoma, a model for protracted, continuous, internal whole-body irradiation. 20660387 2010
Entrez Id: 3014
Gene Symbol: H2AX
H2AX
0.010 Biomarker disease BEFREE We studied the induction, persistence, and disappearance of radiation-induced gamma-H2AX and 53BP1 foci after the first (131)I therapy of patients with differentiated thyroid carcinoma, a model for protracted, continuous, internal whole-body irradiation. 20660387 2010
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.010 GeneticVariation disease BEFREE We showed that NAT2 genotypes and the NAT2 rapid acetylation phenotype are important susceptibility factors for DTC, suggesting that NAT2 detoxification system is involved in this tumor pathogenesis. 19118072 2009
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE We retrospectively studied patients treated for DTC between 2006 and 2013 and compared hs-Tg and IRMA-Tg measurements. 27588675 2017
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.060 GeneticVariation disease BEFREE We report two cases of differentiated thyroid carcinoma associated with ovarian Sertoli-Leydig cell tumor and with a heterozygous DICER1 gene mutation, occurring in two unrelated young girls without pleuropulmonary blastoma. 26983701 2016
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE We report an innovative fiber optic nano-optrode based on Long Period Gratings (LPGs) working in reflection mode for the detection of human Thyroglobulin (TG), a protein marker of differentiated thyroid cancer. 26896794 2016
Entrez Id: 4684
Gene Symbol: NCAM1
NCAM1
0.010 Biomarker disease BEFREE We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. 23015367 2013
Entrez Id: 27255
Gene Symbol: CNTN6
CNTN6
0.010 Biomarker disease BEFREE We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. 23015367 2013
Entrez Id: 53942
Gene Symbol: CNTN5
CNTN5
0.010 Biomarker disease BEFREE We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. 23015367 2013
Entrez Id: 27131
Gene Symbol: SNX5
SNX5
0.010 AlteredExpression disease BEFREE We previously reported that the level of sorting nexin 5 (Snx5), an endosomal translocator, is preferentially decreased during the progression of well-differentiated thyroid carcinoma into poorly differentiated carcinoma. 28771744 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.050 GeneticVariation disease BEFREE We performed a case-control association study of genetic variants in TPO and differentiated thyroid carcinoma (DTC) in 1,586 DTC patients and 1,769 controls including two European populations (Italy: 1,190 DTC and 1,290 controls; Spain: 396 DTC and 479 controls). 23754668 2013
Entrez Id: 140805
Gene Symbol: HT
HT
0.020 Biomarker disease BEFREE We must emphasize that some patients having DTC and also Hashimoto's thyroiditis may had previously received Se supplements or Brazil nuts for a long period of time before DTC was diagnosed and thyroidectomy had followed. 29550852 2018
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE We investigated the usefulness of FDG PET/CT for the early prediction of RAI therapy response in the patients with metastatic differentiated thyroid cancer (DTC). 31237886 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE We identified biomarkers associated with poor prognosis in DTC, including elevated baseline VEGFA and thyroglobulin and the presence of <i>RAS</i> mutations. 31558473 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.020 GeneticVariation disease BEFREE We have developed a home-brew tetracolor break-apart probe able to simultaneously identify the 2 most common genetic alterations in differentiated thyroid carcinoma: RET/PTC variants in papillary thyroid carcinoma and PAX8/PPARg fusion and variants in follicular thyroid carcinoma. 24510380 2014
Entrez Id: 7849
Gene Symbol: PAX8
PAX8
0.030 GeneticVariation disease BEFREE We have developed a home-brew tetracolor break-apart probe able to simultaneously identify the 2 most common genetic alterations in differentiated thyroid carcinoma: RET/PTC variants in papillary thyroid carcinoma and PAX8/PPARg fusion and variants in follicular thyroid carcinoma. 24510380 2014
Entrez Id: 5979
Gene Symbol: RET
RET
0.100 GeneticVariation disease BEFREE We have developed a home-brew tetracolor break-apart probe able to simultaneously identify the 2 most common genetic alterations in differentiated thyroid carcinoma: RET/PTC variants in papillary thyroid carcinoma and PAX8/PPARg fusion and variants in follicular thyroid carcinoma. 24510380 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.060 AlteredExpression disease BEFREE We have characterized TERT promoter methylation, transcription factor binding, and TERT expression levels in five differentiated thyroid cancer (DTC) cell lines and six normal thyroid tissue samples by targeted bisulfite sequencing, ChIP-qPCR, and qRT-PCR. 30664813 2019